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MR-US Fusion Targeted Biopsy Ups Detection of Prostate CA

MR-US Fusion Targeted Biopsy Ups Detection of Prostate CA

Magnetic resonance-ultrasound fusion targeted biopsy detects aggressive tumors better than standard

THURSDAY, Dec. 13 (HealthDay News) -- Targeted biopsy of suspected prostate cancer lesions, identified using magnetic resonance-ultrasound (MR-US) fusion, increases prostate cancer detection and detects aggressive tumors that may be missed by conventional biopsy, according to a study published in the January issue of The Journal of Urology.

Geoffrey A. Sonn, M.D., from the University of California Los Angeles, and colleagues used MR-US fusion prostate biopsy in 171 men (median age, 65 years) undergoing biopsy as part of active surveillance (106 men) or due to increased prostate-specific antigen levels with a prior negative conventional biopsy (65 men). MR-US fusion prostate biopsy locates lesions by magnetic resonance imaging (MRI) and fuses it with real-time ultrasound to generate a three-dimensional prostate model to allow targeted sampling. The men also had conventional systematic biopsies taken.

The researchers identified prostate cancer in 53 percent of men, of whom 38 percent had cancer with Gleason grade 7 or greater. Of these highly-aggressive cancers, 38 percent were detected only by targeted biopsy. Of the 16 men with the highest level of suspicion by MRI (image grade 5 target), 94 percent had prostate cancer.

"Prostate lesions identified on MRI can be accurately targeted with MR-US fusion biopsy in a clinic setting using local anesthesia," Sonn and colleagues conclude. "Targeted prostate biopsy has the potential to improve the diagnosis of prostate cancer and may aid in the selection of patients for active surveillance and focal therapy."

Abstract (http://www.jurology.com/article/S0022-5347%2812%2904714-3/abstract )Full Text (subscription or payment may be required) (http://www.jurology.com/article/S0022-5347%2812%2904714-3/fulltext )